DAT Bootcamp Molecular Genetics Practice Test 2026 – Your Comprehensive All-in-One Guide to Exam Success!

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Deacetylation of histones increases which form of chromatin and thereby decreases which process?

Euchromatin; Transcription

Heterochromatin; Replication

Heterochromatin; Transcription

Deacetylation of histones tightens the DNA–histone interaction, promoting chromatin condensation into heterochromatin. This compact form makes DNA less accessible to RNA polymerase and transcription factors, so transcription is reduced. While replication can occur in condensed chromatin, the direct and primary effect here is the decrease in transcription, not replication.

Euchromatin; Replication

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